ABCD1
Gene Information
- Official Symbol: ABCD1
- Official Name: ATP binding cassette subfamily D member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 215
- UniProt: P33897
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008].
- UniProt Summary: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. {ECO:0000269|PubMed:11248239}.
Pfam Domains GO Terms
Pfam Domains
| ABC membrane 2 |
| ABC tran |
GO Terms
| ATPase-coupled fatty-acyl-CoA transmembrane transporter activity |
| very long-chain fatty-acyl-CoA catabolic process |
| thioester transport |
| fatty-acyl-CoA transport |
| fatty-acyl-CoA catabolic process |
| very long-chain fatty-acyl-CoA metabolic process |
| long-chain fatty acid import into peroxisome |
| very long-chain fatty acid catabolic process |
| purine nucleoside bisphosphate catabolic process |
| nucleoside bisphosphate catabolic process |
| ribonucleoside bisphosphate catabolic process |
| positive regulation of unsaturated fatty acid biosynthetic process |
| positive regulation of fatty acid beta-oxidation |
| long-chain fatty acid catabolic process |
| neuron projection maintenance |
| long-chain fatty acid transporter activity |
| fatty acid derivative catabolic process |
| regulation of unsaturated fatty acid biosynthetic process |
| alpha-linolenic acid metabolic process |
| fatty acid elongation |
| fatty acid transmembrane transport |
| myelin maintenance |
| fatty acid homeostasis |
| positive regulation of fatty acid oxidation |
| integral component of peroxisomal membrane |
| fatty acid beta-oxidation using acyl-CoA oxidase |
| adenine nucleotide transport |
| coenzyme catabolic process |
| linoleic acid metabolic process |
| negative regulation of cytokine production involved in inflammatory response |
| purine ribonucleotide transport |
| peroxisomal membrane transport |
| purine nucleotide transport |
| regulation of fatty acid beta-oxidation |
| positive regulation of fatty acid biosynthetic process |
| regulation of mitochondrial depolarization |
| nucleotide transport |
| positive regulation of lipid catabolic process |
| negative regulation of reactive oxygen species biosynthetic process |
| very long-chain fatty acid metabolic process |
| regulation of fatty acid oxidation |
| regulation of oxidative phosphorylation |
| purine ribonucleotide catabolic process |
| ribonucleotide catabolic process |
| positive regulation of fatty acid metabolic process |
| intracellular lipid transport |
| ADP binding |
| regulation of cytokine production involved in inflammatory response |
| neuron projection organization |
| fatty-acyl-CoA metabolic process |
| regulation of membrane depolarization |
| sulfur compound transport |
| regulation of fatty acid biosynthetic process |
| purine nucleotide catabolic process |
| purine-containing compound catabolic process |
| ATPase-coupled transmembrane transporter activity |
| regulation of lipid catabolic process |
| negative regulation of reactive oxygen species metabolic process |
| sulfur compound catabolic process |
| peroxisomal membrane |
| fatty acid beta-oxidation |
| anion homeostasis |
| long-chain fatty acid transport |
| cofactor catabolic process |
| nucleotide catabolic process |
| peroxisomal transport |
| regulation of mitochondrial membrane potential |
| carbohydrate derivative transport |
| nucleoside phosphate catabolic process |
| fatty acid transport |
| regulation of cellular response to oxidative stress |
| fatty acid oxidation |
| lipid oxidation |
| peroxisome organization |
| positive regulation of lipid biosynthetic process |
| sterol homeostasis |
| regulation of response to oxidative stress |
| regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid metabolic process |
| plasma membrane organization |
| fatty acid catabolic process |
| acyl-CoA metabolic process |
| thioester metabolic process |
| mitochondrial membrane |
| nucleobase-containing small molecule biosynthetic process |
| myelination |
| unsaturated fatty acid metabolic process |
| ensheathment of neurons |
| axon ensheathment |
| peroxisome |
| long-chain fatty acid metabolic process |
| monocarboxylic acid catabolic process |
| fatty acid biosynthetic process |
| regulation of ATP metabolic process |
| organophosphate ester transport |
| carboxylic acid transmembrane transport |
| organic acid transmembrane transport |
| organophosphate catabolic process |
| nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| lipid homeostasis |
| monocarboxylic acid transport |
| negative regulation of inflammatory response |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| regulation of generation of precursor metabolites and energy |
| fatty acid derivative metabolic process |
| regulation of cellular ketone metabolic process |
| regulation of reactive oxygen species metabolic process |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| carbohydrate derivative catabolic process |
| cellular lipid catabolic process |
| lipid modification |
| negative regulation of defense response |
| ATPase activity |
| nucleobase-containing compound transport |
| coenzyme metabolic process |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| negative regulation of cytokine production |
| anion transmembrane transport |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| lipid catabolic process |
| lysosomal membrane |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| purine ribonucleotide metabolic process |
| lipid localization |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| regulation of inflammatory response |
| enzyme binding |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| regulation of lipid metabolic process |
| endomembrane system organization |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| cofactor metabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic anion transport |
| organic cyclic compound catabolic process |
| drug metabolic process |
| monocarboxylic acid metabolic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| anion transport |
| small molecule biosynthetic process |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of cellular response to stress |
| regulation of defense response |
| cellular amide metabolic process |
| ion homeostasis |
| regulation of cellular catabolic process |
| membrane organization |
| protein homodimerization activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| ion transmembrane transport |
| cellular lipid metabolic process |
| oxidation-reduction process |
| regulation of catabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| organonitrogen compound catabolic process |
| identical protein binding |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| transmembrane transport |
| organic cyclic compound biosynthetic process |
| ion transport |
| regulation of response to stress |
| ATP binding |
| intracellular transport |
| negative regulation of biosynthetic process |
| amide transport |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cytochalasin-B 5μM R07 exp349 | -2.39 |
| Arsenic trioxide 60μM R08 exp449 | -1.91 |
| Dinaciclib 0.007μM R07 exp355 | 1.84 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.551 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17846
- Expression level (log2 read counts): 3.03
Expression Distribution
ABCD1 Expression in NALM6 Cells: 3.03
