ACADL

Entrez Summary: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

carnitine catabolic process
carnitine metabolic process, CoA-linked
palmitoyl-CoA oxidase activity
amino-acid betaine catabolic process
long-chain-acyl-CoA dehydrogenase activity
fatty acid beta-oxidation using acyl-CoA dehydrogenase
long-chain fatty acid catabolic process
negative regulation of fatty acid oxidation
carnitine metabolic process
negative regulation of fatty acid biosynthetic process
amino-acid betaine metabolic process
fatty-acyl-CoA binding
negative regulation of fatty acid metabolic process
regulation of fatty acid oxidation
temperature homeostasis
cellular modified amino acid catabolic process
regulation of fatty acid biosynthetic process
negative regulation of lipid biosynthetic process
regulation of cholesterol metabolic process
flavin adenine dinucleotide binding
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
negative regulation of small molecule metabolic process
protein homotetramerization
fatty acid catabolic process
positive regulation of cold-induced thermogenesis
mitochondrial membrane
regulation of steroid metabolic process
long-chain fatty acid metabolic process
monocarboxylic acid catabolic process
regulation of cold-induced thermogenesis
protein tetramerization
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process