ACPP

Entrez Summary: N/A
UniProt Summary: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UMK57 0.6μM R03 exp107	-1.85
Oligomycin-A 20μM R00 exp26	-1.74

thiamine phosphate phosphatase activity
lysophosphatidic acid phosphatase activity
positive regulation of adenosine receptor signaling pathway
thiamine metabolic process
regulation of adenosine receptor signaling pathway
thiamine-containing compound metabolic process
adenosine metabolic process
acid phosphatase activity
5-nucleotidase activity
purine nucleobase metabolic process
positive regulation of G protein-coupled receptor signaling pathway
vesicle membrane
regulation of sensory perception of pain
regulation of sensory perception
nucleobase metabolic process
phosphatase activity
azurophil granule membrane
purine ribonucleoside metabolic process
purine nucleoside metabolic process
filopodium
ribonucleoside metabolic process
water-soluble vitamin metabolic process
protein homotetramerization
pyrimidine-containing compound metabolic process
nucleoside metabolic process
vitamin metabolic process
glycosyl compound metabolic process
regulation of nervous system process
regulation of G protein-coupled receptor signaling pathway
protein tetramerization
lysosomal membrane
dephosphorylation
protein homooligomerization
sulfur compound metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity