ALDH1A1

Entrez Summary: The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011].
UniProt Summary: Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233). {ECO:0000250|UniProtKB:P51647, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

benzaldehyde dehydrogenase (NAD+) activity
androgen binding
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose catabolic process
glyceraldehyde-3-phosphate metabolic process
retinal dehydrogenase activity
ethanol oxidation
aldehyde dehydrogenase (NAD) activity
fructose metabolic process
ethanol metabolic process
NAD binding
retinol metabolic process
negative regulation of cold-induced thermogenesis
hexose catabolic process
cellular aldehyde metabolic process
monosaccharide catabolic process
primary alcohol metabolic process
retinoid metabolic process
antibiotic metabolic process
diterpenoid metabolic process
carbohydrate catabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
regulation of cold-induced thermogenesis
hexose metabolic process
monosaccharide metabolic process
hormone metabolic process
GTPase activator activity
alcohol metabolic process
positive regulation of GTPase activity
generation of precursor metabolites and energy
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
regulation of GTPase activity
drug metabolic process
regulation of hormone levels
positive regulation of hydrolase activity
organophosphate metabolic process