ALDH3B2

Entrez Summary: This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. Altered methylation patterns at this locus have been observed in spermatozoa derived from patients exhibiting reduced fecundity. [provided by RefSeq, Aug 2017].
UniProt Summary: Oxidizes medium and long chain aldehydes into non-toxic fatty acids. {ECO:0000250|UniProtKB:E9Q3E1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aldehyde dehydrogenase [NAD(P)+] activity
3-chloroallyl aldehyde dehydrogenase activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
ethanol catabolic process
aldehyde dehydrogenase (NAD) activity
primary alcohol catabolic process
ethanol metabolic process
antibiotic catabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
lipid droplet
sphingolipid biosynthetic process
antibiotic metabolic process
membrane lipid biosynthetic process
drug catabolic process
sphingolipid metabolic process
membrane lipid metabolic process
alcohol metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
drug metabolic process
lipid biosynthetic process
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process