AMELX

Entrez Summary: This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.78
LJH685 50μM R08 exp433	1.75
FBS-Wisent 0.1 R07 exp426	1.97
iCRT14 30μM R08 exp492	2.05
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.29
Nocodazole 0.2μM R02 exp64	2.42

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

hydroxyapatite binding
positive regulation of tooth mineralization
structural constituent of tooth enamel
regulation of tooth mineralization
positive regulation of odontogenesis
enamel mineralization
tooth mineralization
amelogenesis
positive regulation of collagen biosynthetic process
regulation of odontogenesis
positive regulation of collagen metabolic process
regulation of collagen biosynthetic process
regulation of collagen metabolic process
positive regulation of biomineral tissue development
positive regulation of biomineralization
endocytic vesicle
epithelial to mesenchymal transition
positive regulation of animal organ morphogenesis
odontogenesis of dentin-containing tooth
chondrocyte differentiation
regulation of biomineralization
regulation of biomineral tissue development
biomineralization
biomineral tissue development
odontogenesis
osteoblast differentiation
response to calcium ion
mesenchymal cell differentiation
growth factor activity
cartilage development
response to nutrient
mesenchyme development
connective tissue development
regulation of animal organ morphogenesis
ossification
endoplasmic reticulum lumen
post-translational protein modification
collagen-containing extracellular matrix
response to metal ion
skeletal system development