ARFGAP2

Entrez Summary: N/A
UniProt Summary: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:17760859}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COPI-coated vesicle budding
Golgi transport vesicle coating
COPI coating of Golgi vesicle
COPI vesicle coat
vesicle coating
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
vesicle targeting
vesicle budding from membrane
trans-Golgi network
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
GTPase activator activity
vesicle organization
establishment of organelle localization
Golgi vesicle transport
positive regulation of GTPase activity
regulation of GTPase activity
organelle localization
Golgi membrane
positive regulation of hydrolase activity
membrane organization
Golgi apparatus
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport