ARPC5
Gene Information
- Official Symbol: ARPC5
- Official Name: actin related protein 2/3 complex subunit 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10092
- UniProt: O15511
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Pfam Domains GO Terms
Pfam Domains
| P16-Arc |
GO Terms
| orbitofrontal cortex development |
| actin filament network formation |
| smooth muscle cell migration |
| Arp2/3 protein complex |
| maintenance of cell polarity |
| Arp2/3 complex-mediated actin nucleation |
| muscle cell migration |
| microtubule organizing center localization |
| actin nucleation |
| lamellipodium organization |
| site of double-strand break |
| ephrin receptor signaling pathway |
| positive regulation of actin filament polymerization |
| structural constituent of cytoskeleton |
| limbic system development |
| secretory granule lumen |
| ficolin-1-rich granule lumen |
| positive regulation of protein polymerization |
| growth cone |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| actin filament binding |
| actin cytoskeleton |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| endosome |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| forebrain development |
| regulation of actin filament-based process |
| focal adhesion |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| immune response-regulating cell surface receptor signaling pathway |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| actin cytoskeleton organization |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| leukocyte degranulation |
| regulation of anatomical structure size |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| myeloid cell activation involved in immune response |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulated exocytosis |
| enzyme linked receptor protein signaling pathway |
| brain development |
| leukocyte mediated immunity |
| head development |
| exocytosis |
| membrane organization |
| positive regulation of immune response |
| leukocyte activation |
| regulation of cellular component biogenesis |
| cell migration |
| central nervous system development |
| secretion by cell |
| export from cell |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| movement of cell or subcellular component |
| regulation of immune system process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM131593 0.1μM R01 exp58 | -2.16 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13844
- Expression level (log2 read counts): 6.83
Expression Distribution
ARPC5 Expression in NALM6 Cells: 6.83
