ASPSCR1
Gene Information
- Official Symbol: ASPSCR1
- Official Name: ASPSCR1 tether for SLC2A4, UBX domain containing
- Aliases and Previous Symbols: N/A
- Entrez ID: 79058
- UniProt: Q9BZE9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011].
- UniProt Summary: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4556
- Expression level (log2 read counts): 4.31
ASPSCR1 Expression in NALM6 Cells: 4.31
