BCAT2

Entrez Summary: This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leucine biosynthetic process
isoleucine metabolic process
branched-chain amino acid biosynthetic process
isoleucine catabolic process
valine biosynthetic process
L-valine transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
branched-chain-amino-acid transaminase activity
valine metabolic process
leucine metabolic process
branched-chain amino acid metabolic process
branched-chain amino acid catabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial matrix
small molecule catabolic process
regulation of hormone levels
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
cellular response to cytokine stimulus
organic acid metabolic process
organonitrogen compound catabolic process
response to cytokine
mitochondrion
organonitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process