BMP15

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016].
UniProt Summary: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. {ECO:0000269|PubMed:18227435}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rucaparib 6.5μM R08 exp520	-2.19
GSK-J5 1.5μM R08 exp484	1.7
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.74
IL-3 9ng/ml R08 exp493	1.77
CR131-b 0.005μM R08 exp474	2.11
PF-06409577 20μM R07 exp389	2.31

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

granulosa cell development
granulosa cell differentiation
transforming growth factor beta receptor binding
positive regulation of pathway-restricted SMAD protein phosphorylation
ovarian follicle development
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
female gonad development
BMP signaling pathway
development of primary female sexual characteristics
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
response to BMP
cellular response to BMP stimulus
female sex differentiation
female gamete generation
growth factor activity
cytokine activity
epithelial cell development
transmembrane receptor protein serine/threonine kinase signaling pathway
gonad development
development of primary sexual characteristics
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
sex differentiation
endoplasmic reticulum lumen
post-translational protein modification
reproductive structure development
reproductive system development
cellular response to growth factor stimulus
response to growth factor
developmental process involved in reproduction
epithelial cell differentiation
gamete generation
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
positive regulation of protein phosphorylation
positive regulation of phosphorylation