BTC

Gene Information

Official Symbol: BTC
Official Name: betacellulin
Aliases and Previous Symbols: N/A
Entrez ID: 685
UniProt: P35070
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. {ECO:0000269|PubMed:8570211}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12824
Expression level (log2 read counts): -4.79

Expression Distribution

Screen	Score
RK-33 8μM R08 exp518	-1.87
Sulforaphane 9μM R08 exp526 no dilution day6	2

positive regulation of urine volume
regulation of urine volume
ERBB2 signaling pathway
epidermal growth factor receptor binding
negative regulation of epidermal growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
negative regulation of ERBB signaling pathway
clathrin-coated vesicle membrane
positive regulation of mitotic nuclear division
positive regulation of nuclear division
ERBB signaling pathway
regulation of fibroblast proliferation
regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell division
regulation of ERBB signaling pathway
renal system process
positive regulation of mitotic cell cycle
growth factor activity
positive regulation of protein kinase B signaling
regulation of mitotic nuclear division
regulation of cell division
regulation of nuclear division
regulation of protein kinase B signaling
positive regulation of cell cycle process
MAPK cascade
positive regulation of cell cycle
signal transduction by protein phosphorylation
regulation of body fluid levels
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of organelle organization
regulation of mitotic cell cycle
enzyme linked receptor protein signaling pathway
regulation of cell cycle process
membrane organization
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
positive regulation of cell population proliferation
positive regulation of cell differentiation