C5AR2
Gene Information
- Official Symbol: C5AR2
- Official Name: complement component 5a receptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 27202
- UniProt: Q9P296
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| negative regulation of granulocyte chemotaxis |
| complement component C5a receptor activity |
| complement component C5a signaling pathway |
| negative regulation of neutrophil chemotaxis |
| negative regulation of neutrophil migration |
| negative regulation of interleukin-6 secretion |
| complement receptor mediated signaling pathway |
| negative regulation of leukocyte chemotaxis |
| regulation of interleukin-8 secretion |
| regulation of neutrophil chemotaxis |
| basal plasma membrane |
| regulation of neutrophil migration |
| regulation of granulocyte chemotaxis |
| negative regulation of interleukin-6 production |
| negative regulation of leukocyte migration |
| negative regulation of chemotaxis |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of cytokine secretion |
| regulation of interleukin-8 production |
| apical part of cell |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of leukocyte chemotaxis |
| regulation of complement activation |
| negative regulation of protein secretion |
| regulation of humoral immune response |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| positive regulation of epithelial cell proliferation |
| regulation of leukocyte migration |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| negative regulation of secretion |
| negative regulation of cell migration |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| regulation of epithelial cell proliferation |
| negative regulation of response to external stimulus |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of immune effector process |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of cytokine production |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| ion homeostasis |
| regulation of secretion |
| regulation of cell migration |
| positive regulation of immune response |
| cellular homeostasis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| locomotion |
| G protein-coupled receptor signaling pathway |
| defense response |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11190
- Expression level (log2 read counts): 4.49
Expression Distribution
C5AR2 Expression in NALM6 Cells: 4.49
