C6

Entrez Summary: This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012].
UniProt Summary: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nicotine 3000μM R08 exp510	1.71
Demecolcine 0.03μM R05 exp228	2.06

positive regulation of activation of membrane attack complex
regulation of activation of membrane attack complex
positive regulation of complement activation
membrane attack complex
positive regulation of humoral immune response
cytolysis
regulation of complement activation
regulation of humoral immune response
complement activation, classical pathway
positive regulation of angiogenesis
humoral immune response mediated by circulating immunoglobulin
complement activation
positive regulation of vasculature development
immunoglobulin mediated immune response
B cell mediated immunity
positive regulation of immune effector process
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of angiogenesis
regulation of vasculature development
humoral immune response
in utero embryonic development
regulation of immune effector process
adaptive immune response
activation of immune response
chordate embryonic development
embryo development ending in birth or egg hatching
innate immune response
leukocyte mediated immunity
positive regulation of immune response
defense response to other organism
embryo development
regulation of anatomical structure morphogenesis
immune effector process
regulation of immune response
positive regulation of immune system process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response