C9

Entrez Summary: This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009].
UniProt Summary: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore- forming subunit of the MAC (PubMed:4055801, PubMed:26841934). {ECO:0000269|PubMed:26841934, ECO:0000269|PubMed:4055801, ECO:0000269|PubMed:9212048, ECO:0000269|PubMed:9634479}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MACPF
Ldl recept a

other organism cell membrane
membrane attack complex
complement activation, alternative pathway
cytolysis
cell killing
regulation of complement activation
regulation of humoral immune response
blood microparticle
complement activation, classical pathway
humoral immune response mediated by circulating immunoglobulin
complement activation
immunoglobulin mediated immune response
B cell mediated immunity
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
protein homooligomerization
humoral immune response
regulation of immune effector process
protein complex oligomerization
adaptive immune response
activation of immune response
innate immune response
leukocyte mediated immunity
positive regulation of immune response
defense response to other organism
immune effector process
regulation of immune response
positive regulation of immune system process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
protein-containing complex assembly
extracellular space
regulation of immune system process
protein-containing complex subunit organization
immune response
extracellular region