CARD14

Gene Information

Official Symbol: CARD14
Official Name: caspase recruitment domain family member 14
Aliases and Previous Symbols: N/A
Entrez ID: 79092
UniProt: Q9BXL6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
UniProt Summary: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14- induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6919
Expression level (log2 read counts): 2.33

Expression Distribution

CARD domain binding
activation of NF-kappaB-inducing kinase activity
positive regulation of NIK/NF-kappaB signaling
NIK/NF-kappaB signaling
regulation of NIK/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to tumor necrosis factor
positive regulation of DNA-binding transcription factor activity
response to tumor necrosis factor
activation of protein kinase activity
regulation of DNA-binding transcription factor activity
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
cytokine-mediated signaling pathway
regulation of protein kinase activity
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
regulation of transferase activity
negative regulation of cell death
cellular response to cytokine stimulus
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
programmed cell death
positive regulation of phosphorylation
cell death
response to cytokine
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of signal transduction