CASP5

Gene Information

Official Symbol: CASP5
Official Name: caspase 5
Aliases and Previous Symbols: N/A
Entrez ID: 838
UniProt: P51878
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16419
Expression level (log2 read counts): -2.79

Expression Distribution

Peptidase C14
CARD

NLRP1 inflammasome complex
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type peptidase activity
substantia nigra development
execution phase of apoptosis
neural nucleus development
cellular response to mechanical stimulus
midbrain development
activation of cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of peptidase activity
response to mechanical stimulus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
brain development
positive regulation of hydrolase activity
head development
apoptotic process
central nervous system development
programmed cell death
cell death
response to abiotic stimulus
proteolysis
regulation of hydrolase activity
positive regulation of catalytic activity