CCL25

Entrez Summary: N/A
UniProt Summary: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CCR10 chemokine receptor binding
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte adhesion to vascular endothelial cell
regulation of leukocyte tethering or rolling
chemokine receptor binding
negative regulation of cellular extravasation
regulation of leukocyte adhesion to vascular endothelial cell
regulation of cellular extravasation
CCR chemokine receptor binding
monocyte chemotaxis
negative regulation of leukocyte migration
lymphocyte chemotaxis
mononuclear cell migration
chemokine activity
positive regulation of cell-matrix adhesion
lymphocyte migration
chemokine-mediated signaling pathway
neutrophil chemotaxis
granulocyte chemotaxis
cellular response to chemokine
response to chemokine
neutrophil migration
hormone activity
granulocyte migration
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
negative regulation of leukocyte cell-cell adhesion
myeloid leukocyte migration
leukocyte chemotaxis
cellular response to interferon-gamma
negative regulation of cell-cell adhesion
cellular response to interleukin-1
response to interferon-gamma
regulation of leukocyte migration
response to interleukin-1
cell chemotaxis
positive regulation of ERK1 and ERK2 cascade
regulation of cell-substrate adhesion
cellular response to tumor necrosis factor
negative regulation of cell migration