CFP
Gene Information
- Official Symbol: CFP
- Official Name: complement factor properdin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5199
- UniProt: P27918
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009].
- UniProt Summary: A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. {ECO:0000269|PubMed:20382442}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4619
- Expression level (log2 read counts): 2.39
CFP Expression in NALM6 Cells: 2.39
