CHST11

Gene Information

Official Symbol: CHST11
Official Name: carbohydrate sulfotransferase 11
Aliases and Previous Symbols: N/A
Entrez ID: 50515
UniProt: Q9NPF2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA→GalNAc unit than in IdoA→GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16522
Expression level (log2 read counts): 6.59

Expression Distribution

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
polysaccharide localization
chondroitin 4-sulfotransferase activity
N-acetylgalactosamine 4-O-sulfotransferase activity
embryonic viscerocranium morphogenesis
post-anal tail morphogenesis
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
sulfotransferase activity
chondroitin sulfate metabolic process
respiratory gaseous exchange by respiratory system
chondrocyte development
chondroitin sulfate proteoglycan metabolic process
embryonic cranial skeleton morphogenesis
embryonic digit morphogenesis
cranial skeletal system development
proteoglycan biosynthetic process
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
chondrocyte differentiation
post-embryonic development
proteoglycan metabolic process
embryonic skeletal system morphogenesis
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
embryonic limb morphogenesis
embryonic appendage morphogenesis
embryonic skeletal system development
carbohydrate biosynthetic process
negative regulation of cellular response to growth factor stimulus
limb morphogenesis
appendage morphogenesis
glycosaminoglycan metabolic process
aminoglycan metabolic process
cartilage development
appendage development