CIT

Entrez Summary: This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
UniProt Summary: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-2.71
LJH685 50μM R08 exp433	-1.7

Golgi cisterna
positive regulation of cytokinesis
cortical actin cytoskeleton organization
neuron apoptotic process
cortical cytoskeleton organization
neuron death
cleavage furrow
scaffold protein binding
mitotic cytokinesis
peptidyl-threonine phosphorylation
positive regulation of cell division
PDZ domain binding
regulation of cytokinesis
peptidyl-threonine modification
cytoskeleton-dependent cytokinesis
cytokinesis
actomyosin structure organization
liver development
hepaticobiliary system development
G2/M transition of mitotic cell cycle
SH3 domain binding
Golgi organization
cell cycle G2/M phase transition
midbody
regulation of cell division
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin cytoskeleton
regulation of actin filament organization
mitotic cell cycle phase transition
cell cycle phase transition
positive regulation of cell cycle process
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
protein serine/threonine kinase activity
cytoskeleton
neuronal cell body
regulation of cellular component size
positive regulation of cell cycle
regulation of actin filament-based process