CLCN6

Entrez Summary: This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CBS
Voltage CLC

voltage-gated chloride channel activity
chloride transmembrane transporter activity
antiporter activity
cell volume homeostasis
transmembrane transporter activity
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
inorganic anion transport
regulation of cell size
response to mechanical stimulus
endosome membrane
anion transmembrane transport
lysosomal membrane
regulation of cellular component size
regulation of anatomical structure size
anion transport
inorganic ion transmembrane transport
intracellular membrane-bounded organelle
cellular homeostasis
ion transmembrane transport
response to abiotic stimulus
transmembrane transport
ion transport
ATP binding
homeostatic process