CNKSR3

Gene Information

Official Symbol: CNKSR3
Official Name: CNKSR family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 154043
UniProt: Q6P9H4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269|PubMed:22851176}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12471
Expression level (log2 read counts): 5.23

Expression Distribution

DUF1170
SAM 1
PDZ
CRIC ras sig
SAM 2

positive regulation of sodium ion transmembrane transporter activity
positive regulation of sodium ion transmembrane transport
negative regulation of peptidyl-serine phosphorylation
positive regulation of sodium ion transport
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
negative regulation of ERK1 and ERK2 cascade
regulation of sodium ion transport
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
regulation of peptidyl-serine phosphorylation
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
negative regulation of MAPK cascade
positive regulation of transmembrane transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
regulation of ERK1 and ERK2 cascade
apical plasma membrane
regulation of cation transmembrane transport
regulation of metal ion transport
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of ion transmembrane transport
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
regulation of transmembrane transport
negative regulation of protein modification process
regulation of ion transport
regulation of MAPK cascade
positive regulation of transport
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation