CPNE5

Entrez Summary: N/A
UniProt Summary: Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:0000269|PubMed:23999003}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NMS-873 0.07μM R07 exp380	1.88
Dorsomorphin 5μM R07 exp357	2.12

Copine
C2

positive regulation of dendrite extension
regulation of dendrite extension
calcium-dependent phospholipid binding
cellular response to calcium ion
perikaryon
response to calcium ion
positive regulation of cell growth
positive regulation of developmental growth
cellular response to metal ion
cellular response to inorganic substance
positive regulation of growth
positive regulation of neuron projection development
neuron projection
regulation of developmental growth
positive regulation of neuron differentiation
response to metal ion
positive regulation of cell projection organization
regulation of cell growth
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
response to inorganic substance
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
regulation of growth
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
molecular function
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation