CPSF4

Entrez Summary: N/A
UniProt Summary: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 736/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	24/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

modification by virus of host mRNA processing
modulation by virus of host gene expression
pre-mRNA cleavage required for polyadenylation
mRNA cleavage involved in mRNA processing
tRNA splicing, via endonucleolytic cleavage and ligation
RNA splicing, via endonucleolytic cleavage and ligation
mRNA cleavage and polyadenylation specificity factor complex
modulation by virus of host cellular process
mRNA cleavage
modulation by symbiont of host cellular process
modulation by virus of host morphology or physiology
termination of RNA polymerase II transcription
modification by symbiont of host morphology or physiology
DNA-templated transcription, termination
mRNA 3-end processing
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
modification of morphology or physiology of other organism involved in symbiotic interaction
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
tRNA processing
RNA 3-end processing
regulation of mRNA processing
protein export from nucleus
mRNA transport
modification of morphology or physiology of other organism
interaction with host
nuclear export
RNA phosphodiester bond hydrolysis
tRNA metabolic process
RNA transport
nucleic acid transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome