CTDSP1

Gene Information

Official Symbol: CTDSP1
Official Name: CTD small phosphatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 58190
UniProt: Q9GZU7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5876
Expression level (log2 read counts): 5.74

Expression Distribution

RNA polymerase II CTD heptapeptide repeat phosphatase activity
phosphoprotein phosphatase activity
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
negative regulation of mitotic cell cycle phase transition
protein dephosphorylation
negative regulation of neuron differentiation
negative regulation of cell cycle phase transition
negative regulation of neurogenesis
negative regulation of mitotic cell cycle
dephosphorylation
negative regulation of nervous system development
negative regulation of cell cycle process
negative regulation of cell development
negative regulation of protein phosphorylation
regulation of mitotic cell cycle phase transition
negative regulation of phosphorylation
regulation of cell cycle phase transition
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
regulation of mitotic cell cycle
regulation of neuron differentiation
negative regulation of cell differentiation
regulation of cell cycle process
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
regulation of cell cycle
negative regulation of multicellular organismal process
regulation of protein phosphorylation
generation of neurons
regulation of phosphorylation
neurogenesis