CTSO

Entrez Summary: N/A
UniProt Summary: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Salubrinal 20μM R07 exp399	-1.82
Q15 1 to 2μM on day4 R04 exp164	1.72

cysteine-type endopeptidase activity
lysosome
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
extracellular space
organic substance catabolic process
cellular catabolic process