DDR1

Entrez Summary: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein tyrosine kinase collagen receptor activity
smooth muscle cell-matrix adhesion
smooth muscle cell migration
collagen-activated tyrosine kinase receptor signaling pathway
collagen-activated signaling pathway
regulation of extracellular matrix disassembly
mammary gland alveolus development
mammary gland lobule development
muscle cell migration
branching involved in mammary gland duct morphogenesis
epiboly involved in wound healing
wound healing, spreading of cells
epiboly
mammary gland duct morphogenesis
peptidyl-tyrosine autophosphorylation
embryo implantation
regulation of extracellular matrix organization
mammary gland morphogenesis
lactation
morphogenesis of an epithelial sheet
transmembrane receptor protein tyrosine kinase activity
mammary gland epithelium development
neuron projection extension
collagen binding
body fluid secretion
developmental cell growth
cell growth
gland morphogenesis
developmental growth involved in morphogenesis
regulation of cell-matrix adhesion
cell-matrix adhesion
mammary gland development
branching morphogenesis of an epithelial tube
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
morphogenesis of a branching epithelium
morphogenesis of a branching structure
female pregnancy
cell-substrate adhesion
protein autophosphorylation