DHRS3

Entrez Summary: N/A
UniProt Summary: Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of retinoic acid receptor signaling pathway
NADP-retinol dehydrogenase activity
regulation of retinoic acid receptor signaling pathway
photoreceptor outer segment membrane
retinol dehydrogenase activity
retinol metabolic process
nucleotide binding
cardiac septum morphogenesis
outflow tract morphogenesis
electron transfer activity
primary alcohol metabolic process
lipid droplet
roof of mouth development
retinoid metabolic process
cardiac septum development
diterpenoid metabolic process
bone morphogenesis
terpenoid metabolic process
cellular hormone metabolic process
cardiac chamber morphogenesis
isoprenoid metabolic process
cardiac chamber development
electron transport chain
regulation of ossification
bone development
hormone metabolic process
visual perception
sensory perception of light stimulus
skeletal system morphogenesis
heart morphogenesis
alcohol metabolic process
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
skeletal system development
heart development
regulation of hormone levels
circulatory system development
endoplasmic reticulum membrane
animal organ morphogenesis
cellular lipid metabolic process