DKK4

Gene Information
  • Official Symbol: DKK4
  • Official Name: dickkopf WNT signaling pathway inhibitor 4
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 27121
  • UniProt: Q9UBT3
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 18300
  • Expression level (log2 read counts): -6.6

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1