DNAJC18

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.72
MK-1775 0.32μM R02 exp75	1.86
UM0131023 0.05μM R05 exp248	2.09

DUF1977
DnaJ

cellular response to misfolded protein
response to misfolded protein
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
de novo protein folding
Hsp70 protein binding
chaperone-mediated protein folding
ubiquitin-dependent ERAD pathway
ERAD pathway
cellular response to topologically incorrect protein
response to topologically incorrect protein
protein folding
response to endoplasmic reticulum stress
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
response to organonitrogen compound
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
cellular response to stress
organic substance catabolic process
cellular catabolic process