DPYS

Entrez Summary: Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thymine binding
uracil binding
uracil catabolic process
uracil metabolic process
thymine metabolic process
thymine catabolic process
beta-alanine metabolic process
dihydropyrimidinase activity
pyrimidine nucleobase catabolic process
nucleobase catabolic process
amino acid binding
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
phosphoprotein binding
nucleoside catabolic process
pyrimidine nucleoside metabolic process
nucleobase metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
neurotransmitter metabolic process
protein homotetramerization
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
drug catabolic process
protein tetramerization
carbohydrate derivative catabolic process
cellular amino acid metabolic process
protein homooligomerization
regulation of neurotransmitter levels
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
protein complex oligomerization
nucleobase-containing small molecule metabolic process