DRGX

Entrez Summary: N/A
UniProt Summary: Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
OAR

trigeminal nerve development
detection of temperature stimulus
dorsal spinal cord development
cranial nerve development
nerve development
spinal cord development
neuron migration
detection of external stimulus
detection of abiotic stimulus
sensory perception of mechanical stimulus
response to temperature stimulus
axon guidance
neuron projection guidance
RNA polymerase II regulatory region sequence-specific DNA binding
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
detection of chemical stimulus
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
detection of stimulus
cell morphogenesis
neuron development
cellular component morphogenesis
cell migration
sensory perception
central nervous system development
neuron differentiation
localization of cell
cell motility
plasma membrane bounded cell projection organization
cell projection organization
response to abiotic stimulus
locomotion