DUS1L

Entrez Summary: N/A
UniProt Summary: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LJH685 50μM R08 exp433	2.11
Mitomycin-C 0.06μM R08 exp503	6.53

tRNA dihydrouridine synthase activity
tRNA dihydrouridine synthesis
flavin adenine dinucleotide binding
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
RNA processing
oxidation-reduction process
RNA metabolic process
gene expression