DYNC2LI1

Entrez Summary: This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intraciliary transport particle
intraciliary retrograde transport
dynein heavy chain binding
ATP-dependent microtubule motor activity, minus-end-directed
cytoplasmic dynein complex
ciliary transition zone
intraciliary transport involved in cilium assembly
ciliary tip
intraciliary transport
cytoplasmic microtubule
microtubule-based protein transport
protein transport along microtubule
apical part of cell
regulation of cilium assembly
motile cilium
axoneme
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
ciliary basal body
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
protein-containing complex localization
microtubule-based movement
cilium assembly
cilium organization
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
organelle assembly
regulation of cellular component biogenesis