EFEMP1

Entrez Summary: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009].
UniProt Summary: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. {ECO:0000269|PubMed:19804359, ECO:0000269|PubMed:19887559, ECO:0000269|PubMed:20005202}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

EGF CA
cEGF

epidermal growth factor-activated receptor activity
post-embryonic eye morphogenesis
post-embryonic animal organ morphogenesis
post-embryonic animal morphogenesis
post-embryonic animal organ development
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
epidermal growth factor receptor binding
embryonic eye morphogenesis
epidermal growth factor receptor signaling pathway
regulation of chondrocyte differentiation
regulation of cartilage development
ERBB signaling pathway
post-embryonic development
extracellular matrix structural constituent
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
eye morphogenesis
growth factor activity
visual perception
sensory perception of light stimulus
extracellular matrix
sensory organ morphogenesis
embryonic organ morphogenesis
camera-type eye development
eye development
visual system development
collagen-containing extracellular matrix
sensory system development
embryonic organ development
transmembrane receptor protein tyrosine kinase signaling pathway
sensory organ development
embryonic morphogenesis
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway
calcium ion binding
peptidyl-amino acid modification
negative regulation of developmental process
animal organ morphogenesis
sensory perception