EHD2

Entrez Summary: N/A
UniProt Summary: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Dynamin N
efhand 3

positive regulation of endocytic recycling
regulation of endocytic recycling
plasma membrane tubulation
positive regulation of myoblast fusion
regulation of myoblast fusion
positive regulation of syncytium formation by plasma membrane fusion
regulation of syncytium formation by plasma membrane fusion
positive regulation of myotube differentiation
endocytic recycling
cortical actin cytoskeleton organization
cortical cytoskeleton organization
regulation of myotube differentiation
positive regulation of striated muscle cell differentiation
intercellular bridge
extrinsic component of membrane
caveola
hydrolase activity
recycling endosome membrane
positive regulation of muscle cell differentiation
plasma membrane organization
regulation of striated muscle cell differentiation
microtubule cytoskeleton
regulation of muscle cell differentiation
protein localization to plasma membrane
nucleic acid binding
positive regulation of intracellular transport
endosome membrane
endosomal transport
protein localization to cell periphery
protein domain specific binding
blood coagulation
coagulation
hemostasis
regulation of intracellular transport
GTP binding
endomembrane system organization
wound healing
protein localization to membrane
actin cytoskeleton organization
regulation of body fluid levels