ESRP2

Entrez Summary: N/A
UniProt Summary: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alternative mRNA splicing, via spliceosome
branching involved in salivary gland morphogenesis
epithelial tube branching involved in lung morphogenesis
salivary gland morphogenesis
salivary gland development
exocrine system development
lung morphogenesis
fibroblast growth factor receptor signaling pathway
gland morphogenesis
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
branching morphogenesis of an epithelial tube
regulation of RNA splicing
morphogenesis of a branching epithelium
mRNA binding
morphogenesis of a branching structure
lung development
respiratory tube development
positive regulation of epithelial cell proliferation
respiratory system development
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
epithelial tube morphogenesis
regulation of epithelial cell proliferation
RNA splicing
gland development
morphogenesis of an epithelium
mRNA processing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
tissue morphogenesis
tube morphogenesis
mRNA metabolic process
enzyme linked receptor protein signaling pathway
tube development
RNA processing
positive regulation of cell population proliferation
animal organ morphogenesis