ESYT3

Entrez Summary: N/A
UniProt Summary: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269|PubMed:23791178}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

organelle membrane contact site
endoplasmic reticulum-plasma membrane tethering
endoplasmic reticulum-plasma membrane contact site
intrinsic component of endoplasmic reticulum membrane
endoplasmic reticulum localization
phosphatidylethanolamine binding
phosphatidylcholine binding
calcium-dependent phospholipid binding
extrinsic component of cytoplasmic side of plasma membrane
glycosphingolipid metabolic process
phosphatidylinositol binding
glycolipid metabolic process
liposaccharide metabolic process
sphingolipid metabolic process
organelle localization by membrane tethering
membrane docking
membrane lipid metabolic process
lipid transport
lipid localization
organelle localization
calcium ion binding
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
integral component of plasma membrane