FAM46C

Entrez Summary: N/A
UniProt Summary: Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase. {ECO:0000305|PubMed:27060136}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BVD-523 15μM R02 exp67	2.03
Trametinib 10μM R02 exp83	2.27

RNA adenylyltransferase activity
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
negative regulation of mRNA metabolic process
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
regulation of mRNA metabolic process
in utero embryonic development
posttranscriptional regulation of gene expression
chordate embryonic development
embryo development ending in birth or egg hatching
regulation of cellular catabolic process
embryo development
regulation of catabolic process
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
positive regulation of gene expression