FBXO22

Gene Information

Official Symbol: FBXO22
Official Name: F-box protein 22
Aliases and Previous Symbols: N/A
Entrez ID: 26263
UniProt: Q8NEZ5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269|PubMed:22972877}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3442
Expression level (log2 read counts): 6.73

Expression Distribution

F-box
FIST C

regulation of skeletal muscle fiber development
regulation of skeletal muscle tissue development
regulation of myotube differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
regulation of striated muscle cell differentiation
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of striated muscle tissue development
Z disc
regulation of muscle tissue development
regulation of muscle organ development
positive regulation of cellular protein catabolic process
cellular response to starvation
regulation of muscle cell differentiation
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
response to starvation
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
cellular response to nutrient levels
ubiquitin-protein transferase activity
regulation of cellular protein catabolic process
nucleocytoplasmic transport
cellular response to extracellular stimulus
nuclear transport
protein polyubiquitination
cellular response to external stimulus
positive regulation of proteolysis
post-translational protein modification
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
response to nutrient levels
ubiquitin-dependent protein catabolic process
response to extracellular stimulus
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process