FGF1

Gene Information

Official Symbol: FGF1
Official Name: fibroblast growth factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2246
UniProt: P05230
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:20422052, ECO:0000269|PubMed:23469107, ECO:0000269|PubMed:8663044}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15890
Expression level (log2 read counts): -1.6

Expression Distribution

Screen	Score
Citral 75μM R06 exp275	1.76
Temozolomide 200μM R04 exp189	1.89

branch elongation involved in ureteric bud branching
positive regulation of cholesterol biosynthetic process
positive regulation of sterol biosynthetic process
ureteric bud elongation
regulation of endothelial tube morphogenesis
positive regulation of cholesterol metabolic process
regulation of cell chemotaxis to fibroblast growth factor
regulation of endothelial cell chemotaxis to fibroblast growth factor
S100 protein binding
organ induction
branch elongation of an epithelium
positive regulation of steroid biosynthetic process
fibroblast growth factor receptor binding
regulation of endothelial cell chemotaxis
positive regulation of alcohol biosynthetic process
axis elongation
developmental induction
positive regulation of steroid metabolic process
activation of protein kinase B activity
regulation of animal organ formation
positive regulation of sprouting angiogenesis
Hsp70 protein binding
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
branching involved in ureteric bud morphogenesis
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of cholesterol metabolic process
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
regulation of sprouting angiogenesis
cellular response to heat
regulation of alcohol biosynthetic process
nephron tubule development
positive regulation of lipid biosynthetic process
renal tubule development
fibroblast growth factor receptor signaling pathway
positive regulation of animal organ morphogenesis