GAL3ST1

Entrez Summary: N/A
UniProt Summary: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000250, ECO:0000269|PubMed:8830034}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

galactosylceramide sulfotransferase activity
galactosylceramide biosynthetic process
galactolipid biosynthetic process
glycosylceramide biosynthetic process
galactosylceramide metabolic process
galactolipid metabolic process
glycosylceramide metabolic process
glycosphingolipid biosynthetic process
sulfotransferase activity
ceramide biosynthetic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
protein N-linked glycosylation
ceramide metabolic process
sphingolipid biosynthetic process
myelination
ensheathment of neurons
axon ensheathment
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
amide biosynthetic process
spermatogenesis
male gamete generation
lipid biosynthetic process
carbohydrate derivative biosynthetic process
Golgi membrane
gamete generation
cellular amide metabolic process
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
cellular lipid metabolic process