GDF1

Gene Information

Official Symbol: GDF1
Official Name: growth differentiation factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2657
UniProt: P27539
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016].
UniProt Summary: May mediate cell differentiation events during embryonic development.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6653
Expression level (log2 read counts): -2.79

Expression Distribution

TGF beta
TGFb propeptide

transforming growth factor beta receptor binding
positive regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
BMP signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
response to BMP
cellular response to BMP stimulus
growth factor activity
cytokine activity
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cellular response to growth factor stimulus
response to growth factor
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation
response to endogenous stimulus
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
extracellular space
positive regulation of cellular protein metabolic process
cell development
positive regulation of signal transduction
regulation of cell death
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process