GRIN1
Gene Information
- Official Symbol: GRIN1
- Official Name: glutamate ionotropic receptor NMDA type subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2902
- UniProt: Q05586
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Lig chan |
| CaM bdg C0 |
| ANF receptor |
| Lig chan-Glu bd |
| SBP bac 3 |
GO Terms
| propylene metabolic process |
| olfactory learning |
| cellular alkene metabolic process |
| response to glycine |
| pons maturation |
| olefin metabolic process |
| glutamate-gated calcium ion channel activity |
| conditioned taste aversion |
| male mating behavior |
| hindbrain maturation |
| central nervous system maturation |
| neurotransmitter binding |
| NMDA glutamate receptor activity |
| excitatory chemical synaptic transmission |
| glutamate binding |
| pons development |
| olfactory behavior |
| NMDA selective glutamate receptor complex |
| suckling behavior |
| synaptic cleft |
| prepulse inhibition |
| glycine binding |
| chemosensory behavior |
| mating behavior |
| regulation of respiratory gaseous exchange |
| ionotropic glutamate receptor signaling pathway |
| synaptic membrane |
| startle response |
| regulation of long-term neuronal synaptic plasticity |
| positive regulation of excitatory postsynaptic potential |
| synaptic transmission, glutamatergic |
| reproductive behavior |
| excitatory synapse |
| response to amphetamine |
| long-term memory |
| protein heterotetramerization |
| response to morphine |
| mating |
| response to isoquinoline alkaloid |
| protein localization to postsynaptic membrane |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
| regulation of NMDA receptor activity |
| cellular response to amyloid-beta |
| modulation of excitatory postsynaptic potential |
| glutamate receptor signaling pathway |
| response to amine |
| visual learning |
| response to amyloid-beta |
| terminal bouton |
| integral component of postsynaptic density membrane |
| positive regulation of reactive oxygen species biosynthetic process |
| response to bronchodilator |
| social behavior |
| intraspecies interaction between organisms |
| calcium channel activity |
| regulation of neuronal synaptic plasticity |
| visual behavior |
| positive regulation of calcium ion transport into cytosol |
| protein localization to synapse |
| positive regulation of nervous system process |
| excitatory postsynaptic potential |
| regulation of glutamate receptor signaling pathway |
| calcium ion transmembrane import into cytosol |
| multi-organism behavior |
| chemical synaptic transmission, postsynaptic |
| calcium ion transport into cytosol |
| sensory perception of pain |
| regulation of neurotransmitter receptor activity |
| adult locomotory behavior |
| response to anesthetic |
| associative learning |
| amyloid-beta binding |
| regulation of reactive oxygen species biosynthetic process |
| feeding behavior |
| ephrin receptor signaling pathway |
| cytosolic calcium ion transport |
| regulation of dendrite morphogenesis |
| positive regulation of reactive oxygen species metabolic process |
| regulation of calcium ion transport into cytosol |
| regulation of postsynaptic membrane potential |
| regulation of synapse assembly |
| protein heterooligomerization |
| neuromuscular process |
| metencephalon development |
| response to alkaloid |
| response to amino acid |
| cerebral cortex development |
| memory |
| synaptic vesicle |
| positive regulation of calcium ion transport |
| response to ethanol |
| xenobiotic metabolic process |
| anatomical structure maturation |
| regulation of nervous system process |
| adult behavior |
| negative regulation of neuron apoptotic process |
| calcium-mediated signaling |
| learning |
| dendritic spine |
| protein tetramerization |
| regulation of dendrite development |
| positive regulation of cysteine-type endopeptidase activity |
| hindbrain development |
| positive regulation of synaptic transmission |
| regulation of cation channel activity |
| positive regulation of endopeptidase activity |
| regulation of signaling receptor activity |
| pallium development |
| regulation of reactive oxygen species metabolic process |
| response to ammonium ion |
| regulation of axonogenesis |
| cellular response to xenobiotic stimulus |
| regulation of synaptic plasticity |
| positive regulation of peptidase activity |
| locomotory behavior |
| calcium ion transmembrane transport |
| postsynaptic membrane |
| calmodulin binding |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| response to nutrient |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| protein localization to cell periphery |
| response to alcohol |
| developmental maturation |
| regulation of cysteine-type endopeptidase activity |
| regulation of calcium ion transport |
| calcium ion transport |
| postsynaptic density |
| telencephalon development |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of transmembrane transporter activity |
| protein-containing complex binding |
| synapse |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| divalent metal ion transport |
| cognition |
| response to xenobiotic stimulus |
| divalent inorganic cation transport |
| response to antibiotic |
| regulation of cell morphogenesis involved in differentiation |
| response to light stimulus |
| regulation of neuron death |
| neuron projection |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| second-messenger-mediated signaling |
| response to acid chemical |
| glutamatergic synapse |
| positive regulation of proteolysis |
| negative regulation of response to external stimulus |
| MAPK cascade |
| regulation of metal ion transport |
| forebrain development |
| signal transduction by protein phosphorylation |
| regulation of endopeptidase activity |
| dendrite |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| divalent inorganic cation homeostasis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| response to nutrient levels |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| protein complex oligomerization |
| response to extracellular stimulus |
| cell junction |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| behavior |
| regulation of system process |
| cellular response to organonitrogen compound |
| cation transmembrane transport |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| brain development |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| head development |
| ion homeostasis |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| cation transport |
| sexual reproduction |
| multicellular organism reproduction |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| ion transmembrane transport |
| regulation of cellular component biogenesis |
| sensory perception |
| protein phosphorylation |
| central nervous system development |
| positive regulation of transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| response to drug |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| response to abiotic stimulus |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| transmembrane transport |
| phosphorylation |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trimetrexate 0.03μM R08 exp535 | -1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9797
- Expression level (log2 read counts): 1.12
Expression Distribution
GRIN1 Expression in NALM6 Cells: 1.12
