GSC

Entrez Summary: This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. {ECO:0000250, ECO:0000269|PubMed:24290375}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neural crest cell fate specification
neural crest cell fate commitment
stem cell fate specification
stem cell fate commitment
neural crest formation
dorsal/ventral neural tube patterning
middle ear morphogenesis
signal transduction involved in regulation of gene expression
neural tube patterning
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription factor binding
epithelial to mesenchymal transition
dorsal/ventral pattern formation
muscle organ morphogenesis
cell fate specification
neural crest cell differentiation
embryonic skeletal system morphogenesis
ear morphogenesis
embryonic skeletal system development
mesenchymal cell differentiation
stem cell differentiation
gastrulation
neural tube development
transcription factor complex
negative regulation of Wnt signaling pathway
ear development
mesenchyme development
skeletal system morphogenesis
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
sensory organ morphogenesis
nuclear body
embryonic organ morphogenesis
muscle organ development
regionalization
regulation of Wnt signaling pathway
forebrain development
embryonic organ development
pattern specification process
muscle structure development