GSTA4

Entrez Summary: N/A
UniProt Summary: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). {ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GST C
GST N

glutathione derivative biosynthetic process
glutathione derivative metabolic process
glutathione transferase activity
glutathione metabolic process
xenobiotic metabolic process
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
cellular modified amino acid metabolic process
response to xenobiotic stimulus
sulfur compound metabolic process
cofactor metabolic process
peptide metabolic process
cellular amide metabolic process
protein homodimerization activity
identical protein binding
organonitrogen compound biosynthetic process