GSTO2

Entrez Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].
UniProt Summary: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutathione dehydrogenase (ascorbate) activity
methylarsonate reductase activity
L-ascorbic acid metabolic process
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione derivative metabolic process
glutathione transferase activity
response to arsenic-containing substance
water-soluble vitamin metabolic process
cellular oxidant detoxification
cellular detoxification
oxidoreductase activity
vitamin metabolic process
detoxification
xenobiotic metabolic process
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
monosaccharide metabolic process
cellular response to toxic substance
coenzyme metabolic process
response to xenobiotic stimulus
sulfur compound metabolic process
cofactor metabolic process
carbohydrate metabolic process
response to toxic substance
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
organonitrogen compound biosynthetic process
small molecule metabolic process