GYG2

Entrez Summary: This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010].
UniProt Summary: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
glycogenin glucosyltransferase activity
glucan biosynthetic process
glycogen biosynthetic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
cellular carbohydrate biosynthetic process
energy reserve metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
carbohydrate biosynthetic process
cellular carbohydrate metabolic process
energy derivation by oxidation of organic compounds
generation of precursor metabolites and energy
carbohydrate metabolic process
oxidation-reduction process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process