HOXC11

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Aminopterin 0.005μM R07 exp335	-1.94
GSK461364A 0.005μM R03 exp125	1.76

Homeobox
DUF3528

embryonic skeletal joint morphogenesis
embryonic skeletal joint development
organ induction
developmental induction
proximal/distal pattern formation
regulation of animal organ formation
embryonic digit morphogenesis
endoderm development
positive regulation of animal organ morphogenesis
metanephros development
embryonic skeletal system morphogenesis
embryonic limb morphogenesis
embryonic appendage morphogenesis
embryonic skeletal system development
limb morphogenesis
appendage morphogenesis
appendage development
limb development
anterior/posterior pattern specification
skeletal system morphogenesis
regulation of animal organ morphogenesis
kidney development
renal system development
embryonic organ morphogenesis
urogenital system development
regionalization
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
animal organ morphogenesis
embryo development
regulation of anatomical structure morphogenesis
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
positive regulation of transcription, DNA-templated